Gausachs et al. found that somatic hypermethylation of MLH1 is an accurate and cost-effective pre-screening method in patients affected by CRC with mismatch repair (MMR) deficiency and positive FH, for the selection of patients that are candidates for MLH1 germline analysis when LS is suspected and MLH1 protein expression is absent [19]. Here, MLH1 is linked to colorectal carcinoma.