UGT1A1 activity has been linked to the development of indirect hyperbilirubinemia in both clinical GS and post-hepatitis hyperbilirubinemia, raising the question of whether “Gilbert’s-like” aberrations in bilirubin metabolism are part of the spectrum of hyperbilirubinemia in post-chronic persistent hepatitis and what is the role of gene UGT1A1 polymorphisms in this condition. The gene discussed is UGT1A1; the disease is Hyperbilirubinemia.