In this study, we have conducted the first genome-wide screening of genetic variation in a wild reservoir of MTC infection across a temporal scale of increasing TB prevalence, providing new insights into the identification of SNPs (i.e. rs81465339, rs81394585, rs81423166) and candidate genes (i.e. LOC102164072, BDNF/NT-3, NTRK2, CDH8, IGSF21) associated with genetic susceptibility to TB in the Eurasian wild boar. Here, IGSF21 is linked to infection.