In addition, 2 PMs were found in BAG3 and RBM20. In our DCM cohort, most variants were private and only 4 of the 118 variants were detected in unrelated patients; in particular, a novel VUS in LMNA (p.E115M) was shared by 3 unrelated patients (Supplementary Table 4). The gene discussed is BAG3; the disease is familial dilated cardiomyopathy.