ACKR1 and hemoglobinopathy: Accordingly, present-day Native Amerindians do not show genetic traits conferring protection from malaria infection or severity, such as hemoglobinopathies, sickle-cell trait, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and Duffy antigen/receptor for chemokines (DARC) negativity, which have been selected in African and Eurasian populations heavily exposed to malaria4.