While direct application of HAdV5HVR7 to the subcutaneous tumor led to a tumor-to-liver ratio of 300 of the transgene signal, the shielded EGFR-retargeted HAdV5HVR7 resulted in 9200 times higher payload activity in the tumor, in both cases upon intratumoral injection (Fig. 9d). Here, EGFR is linked to neoplasm.