However, no increase in tumor targeting by the retargeting adapter was detected after intravenous administration, compared with the knob-blocking adapter, although the tumor-to-liver ratio of payload expression was significantly increased by a factor of around 170 in the EGFR+ tumor model and by 25-fold in the HER2+ tumor model (Fig. 4c, d), compared to the naked HAdV5HVR7. Here, EGFR is linked to neoplasm.