However, many neurons in the ipsilateral hippocampus showed prominent Tau inclusions that were labeled with high-intensity AT8 staining in the mice with AD p-Tau injection and treated with mouse IgG (Fig. 4a), which indicates that injected AD p-Tau acts as Tau seeds and induces the host-overexpressed Tau to form NFTs in seeded neurons. This evidence concerns the gene MAPT and Alzheimer disease.