Consistently, the amyloid plaque load was larger in the AD p-Tau-injected animals than in saline/43D and AD p-Tau/43D mice; 43D treatment showed a trend to decrease the plaque load in the AD p-Tau/43D mice compared with AD p-Tau/IgG mice (Fig. 5c and d). The gene discussed is MAPT; the disease is Alzheimer disease.