The Tau pathology made up of the p-Tau is also a hallmark of several neurodegenerative disorders known as tauopathies, which include frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, Pick disease, Guam Parkinsonism-dementia complex, and chronic traumatic encephalopathy. Here, MAPT is linked to Classical progressive supranuclear palsy.