MAPT and Alzheimer disease: The number of AT8 high-intensity positive tangles in the AD p-Tau-injected hippocampus were 0, 800, and 1500 at 3 (AD p-Tau/saline; n = 2), 6 (AD p-Tau/saline; n = 2), and 7.5 (AD p-Tau/IgG; n = 7) weeks after AD p-Tau injection, which clearly demonstrated that AD p-Tau time-dependently templated host Tau into tangles in 3 × Tg-AD mice (Fig. 2b, c).