HCC is the third most common cause of cancer mortality worldwide, and tumour recurrence due to de novo tumours and dissemination are the predominant causes leading to the high mortality [1, 4, 32, 33].The present study demonstrated that ITGB5 is a critical regulator of the tumorigenic potential of HCC, not only facilitating cancer cell growth but also promoting cell migration. The gene discussed is ITGB5; the disease is neoplasm.