Based on the fact that miR-23a/CXCR4 regulates neuropathic pain by directly targeting TXNIP and TXNIP regulates the expression of NLRP3 inflammasome in neuropathic pain, we supposed to investigate whether miR-23a or CXCR4 could regulate NLRP3 inflammasome via TXNIP. This evidence concerns the gene NLRP3 and neuropathic pain.