TXNIP and neuropathic pain: It is notable that CXCR4 pulled down by TXNIP is increased by over 3-fold, while the expression of CXCR4 is almost increased by about 1.4-fold in pain models, suggesting there is stronger affinity or binding potency between spinal CXCR4 and TXNIP, at least, in the spinal cord of neuropathic pain mice.