GADD45 promoter hypermethylation is frequently detected in tumor cell lines, including 85% of non-Hodgkin’s lymphoma, 50% of Hodgkin lymphoma, 73% of nasopharngeal, 50% of cervical, 29% of esophageal, and 40% of lung carcinomas [7]. This evidence concerns the gene GADD45A and neoplasm.