PDE5A and benign prostatic hyperplasia: Men with BPH may be prescribed phosphodiesterase type 5 (PDE5) inhibitors such as tadalafil, although the more commonly prescribed medications for male LUTS attributed to BPH are alpha-adrenergic agents to relax the urethral and prostate smooth muscle and/or 5-alpha reductase inhibitors to reduce androgen production and prostate growth.