MAPT and Alzheimer disease: The characteristic changes in the brain tissue of AD patients are: (a) hyperphosphorylated tau protein rich intra-neuronal neurofibrillary tangles (NFT); (b) extracellular senile plaques of aggregated amyloid β (Aβ) peptides; and (c) brain tissue atrophy, starting in the entorhinal region and the temporal lobe, and progressing to the limbic system and the neocortex [4,5,6,7,8,9].