In contrast to observations described above that revealed an oncogenic role for RhoB in glioblastoma, Forget et al. reported that RhoB protein expression levels are inversely related to tumor malignancy in a series of 24 human brain tumors including astrocytomas, anaplastic astrocytomas, glioblastomas and pilocytic astrocytomas [73]. This evidence concerns the gene RHOB and brain neoplasm.