By measuring the N/D ratio of urinary angiotensinogen, we and others have shown that the circadian rhythm of intrarenal RAS activation in subjects with CKD may lead to renal damage and hypertension [84,85], while Isobe et al. (2015) have demonstrated that the N/D ratio of urinary angiotensinogen is positively correlated with the N/D ratios of urinary protein, albumin excretion, and BP [84], suggesting that activation of the intrarenal RAS plays a critical role in the pathophysiology of the dipping pattern of BP. The gene discussed is AGT; the disease is hypertensive disorder.