Moreover, enhanced lipid accumulation in the aorta is also observed in mice deficient in the nuclear transcription factor Rev-erbα, which triggers atherosclerosis through the increased expression and secretion of the pro-atherogenic cytokine IL-18 in primary macrophages and the increased expression of Nlrp3, an inflammasome component involved in IL-18 maturation [37]. The gene discussed is IL18; the disease is atherosclerosis.