Following a functional analysis of rat Bmal1 promoter polymorphisms and based on the candidate SNPs, the authors performed translational research in humans, which revealed a strong association of BMAL1 SNPs with hypertension (three-marker haplotypes; rs6486121, rs3789327, rs969485) and diabetes (two-marker haplotypes; rs7950226, rs11022775) in humans, although the associated SNPs were not from the same haplotypes. This evidence concerns the gene BMAL1 and Hypertension.