By means of similar mechanisms, ICH has also been shown to cause cell cycle arrest at G2/M phase, induce growth inhibition, and commits the human LNCaP prostate cancer cells toward apoptosis by activating EGR-1 and NAG-1 through c-Jun N-terminal kinase (JNK)-dependent pathway instead of Erk way. Here, GDF15 is linked to Familial prostate cancer.