TP53 and glioblastoma: Specifically, the chemotherapeutic effects of a chloroform extract of A. sinensis (AS-C) displayed impressive effects, suppressing the proliferation of glioblastoma multiform (GBM) cells both in vitro and in vivo through both p53-dependent and p53-independent pathways to induce apoptosis without cytotoxic effects on normal fibroblast cells.