KIT and Miyoshi myopathy: As examples, loss of SPRED1, as well as copy number gains or mutation of V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene (KIT) and V-Myc Avian Myelocytomatosis Viral Oncogene Homolog (MYC) [27], could all contribute to alternative means of promoting MAPK pathway activation in MM.