PRNP and Creutzfeldt Jacob disease: The ~21 kDa fragment, similar to the PrP-res type 1 described in CJD (i. e., the classic triad of PrP27-30 fragments with variable glycosylation), is typically found in some cases, whereas the ~8 kDa fragment is found in all cases, and has been taken to represent a pathognomonic characteristic of GSS [31, 43].