Interestingly, some of these SNPs enriched in the same or neighboring super enhancers, the strong enrichment of T2D super enhancer SNPs on the chromosome 2p21 (THADA), 3q21.1 (ADCY5), 4p16.1 (WFS1) and 10q25.2 (TCF7L2) are rather striking (Fig 1). The gene discussed is ADCY5; the disease is type 2 diabetes mellitus.