Interestingly, some of these SNPs enriched in the same or neighboring super enhancers, the strong enrichment of T2D super enhancer SNPs on the chromosome 2p21 (THADA), 3q21.1 (ADCY5), 4p16.1 (WFS1) and 10q25.2 (TCF7L2) are rather striking (Fig 1). This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.