This was also demonstrated by the increased HLA-DR expression after co-infection of FPCIITAH6 with the FPgp or FPenv recombinants, and the high CIITA expression by confocal microscopy using the same single recombinants, which was not observed after infection with the double recombinants where CIITA was under the SP promoter. The gene discussed is CIITA; the disease is coinfection.