Experimental autoimmune encephalomyelitis (EAE) is a well-characterized experimental model for MS that is induced by immunization of susceptible animal strains with myelin proteins or immunodominant peptide epitopes from proteins such as myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.