Our preliminary data showed significantly elevated concentrations of IFN-γ (p < 0.05), TNF-α (p < 0.001), IL-5 (p < 0.01), and IL-6 (p < 0.05) cytokines at luminal (insert) compartment primarily after cell exposure to ALS plasma (Figure 2). The gene discussed is IFNG; the disease is amyotrophic lateral sclerosis.