While the traditional cooperative role of Glo1/Glo2 appears valid in PCa progression, in PCa genesis it appears that Glo1 and Glo2 have independent roles, not working sequentially as a metabolic system, helping cast further doubt on whether the glyoxalase pathway is really a pathway [101], at least in some settings. The gene discussed is GLO1; the disease is posterior cortical atrophy.