The TAT–DRBD system was used for intracranial delivery of epidermal growth factor receptor (EGFR) and AKT serine/threonine kinase 2 (Akt2) siRNAs to treat glioblastoma in mouse models and it was showed to induce a lethal RNAi responses and increased animal survival [162]. Here, EGFR is linked to glioblastoma.