For instances, mTOR inhibitors induce autophagy in lung cancer, glioma, mantle cell lymphoma and disseminated gastric cancer cells.16, 17, 18, 19 In this study, we demonstrated that TcdB suppressed mTORC1 activity as demonstrated by reduced phosphorylation of mTOR and its substrate p70‐S6K. This evidence concerns the gene RPS6KB1 and glioma.