For instances, mTOR inhibitors induce autophagy in lung cancer, glioma, mantle cell lymphoma and disseminated gastric cancer cells.16, 17, 18, 19 In this study, we demonstrated that TcdB suppressed mTORC1 activity as demonstrated by reduced phosphorylation of mTOR and its substrate p70‐S6K. The gene discussed is RPS6KB1; the disease is central nervous system cancer.