As mentioned previously, RYBP is a multifaceted adaptor involved in both the PcG complex and apoptosis; indeed, several studies have demonstrated dysregulated expression of RYBP in various human tumour tissues, including prostate, lung, liver, breast and cervical cancers, as well as Hodgkin's lymphoma (HL), and glioblastoma multiforme 43, 50, 51, 52, 53, 54, 55, 56, 57. This evidence concerns the gene RYBP and glioblastoma.