However, non‐specific NF‐κB inhibition may lead to side effects that decrease the drug's therapeutic efficacy.29 Glucocorticoids, the most common anti‐RA drugs, are considered to be the most powerful non‐specific inhibitors of NF‐κB but lead to osteoporosis and dysfunction of the hypothalamic‐pituitary‐adrenal axis.30 Therefore, there is a clear need for anti‐inflammatory agents that are cell specific and have a lower potential toxicity. The gene discussed is NFKB1; the disease is osteoporosis.