Currently, multiple steps of NF‐κB activation can be targeted (IKKs, IκBα or p65/p50 subunit) with various available approaches, that is small molecule peptides or nucleic acids.14, 15 The NEMO‐binding domain (NBD) peptide is a classic NF‐κB inhibitor that can specifically bind to the NEMO domain and interfere with IκB kinase (IKK) complex formation.16 Therefore, we hypothesize that liposomes coated with HAP‐1 and loaded with the NBD peptide (HAP‐lipo/NBD) may be able to target and inhibit NF‐κB in SFs of the inflamed synovium, thereby alleviating arthritis. The gene discussed is NFKB1; the disease is Arthritis.