The GDF15 expression was significantly upregulated in HCC cells treated with cisplatin (Huh7, 6.9 μg/mL; HepG2, 65.2 μg/mL) or with doxorubicin (Huh7, 0.2 μg/mL; HepG2, 1 μg/mL) (Fig. 1A), whereas VEGF expression was markedly decreased (Fig. 1B). The gene discussed is GDF15; the disease is hepatocellular carcinoma.