Pancreatic inflammatory foci of MRL/MpJ mice with spontaneous AIP mainly consist of CD3+ T cells, with CD4+ T cells being predominant over CD8+ T cells (Figure 4A).10, 12, 13, 16 Autoimmune foci that were induced by the transfer of unpurified splenocytes (Figure 4B), CD3+ T cells (Figure 4C), CD4+ T cells (Figure 4D) and CD8+ T cells (Figure 4E) also largely consisted of CD3+ T cells, and higher numbers were observed for CD4+ T cells than for the CD8+ counterpart. This evidence concerns the gene CD4 and autoimmune pancreatitis.