It has been reported that S100P acts as a ligand for the receptor for advanced glycation endproducts (RAGE) and activates ERK1/2, NF‐kB and the JAK/STAT pathway.39, 40, 41 The S100P/RAGE signalling pathway contributes to cancer progression by triggering the oncogenic miR‐15542 and miR‐2143 in colon cancer. Here, MAPK3 is linked to colonic neoplasm.