S100P and colorectal carcinoma: Conversely, Trx‐1 knockdown inhibits CRC cell migration and invasion abilities in vitro and liver metastasis in vivo.15 Similar results were also obtained in CRC cells with S100P overexpression or knockdown.19, 22 Trx‐1 promotes CRC invasion and metastasis through crosstalk with S100P.15 These results suggested that interplay between Trx‐1 and S100P plays important roles in CRC metastasis.