S100P and colorectal carcinoma: S100P was reported to promote EMT and the invasion and metastasis of CRC by activating RAGE/ERK signalling.48 Moreover, Jiang et al. demonstrated that Trx‐1 is a critical mediator of TGF‐beta induced EMT in salivary adenoid cystic carcinoma.49 S100P could promote cancer invasion and metastasis by promoting the EMT in CRC48, 50 and lung cancer.21