S100P was reported to promote EMT and the invasion and metastasis of CRC by activating RAGE/ERK signalling.48 Moreover, Jiang et al. demonstrated that Trx‐1 is a critical mediator of TGF‐beta induced EMT in salivary adenoid cystic carcinoma.49 S100P could promote cancer invasion and metastasis by promoting the EMT in CRC48, 50 and lung cancer.21 The gene discussed is S100P; the disease is cancer.