Liu S et al. reported that HBXIP induces S100A4 expression through PI3K/AKT signalling pathway in breast cancer cells.62 S100P could also activate AKT signalling in lung cancer cells.21 Indeed, we observed that blocking AKT signalling partially reversed S100P‐ or Trx‐1‐induced S100A4 expression, EMT, and migration and invasion of CRC cells. This evidence concerns the gene LAMTOR5 and lung cancer.