Several conditions (including aging, environmental insults, genetic variations of the SNCA promoter region, and mutations of the glucocerebrosidase gene) are associated with α‐synuclein elevation, underscoring the possibility that protein spreading may also occur under these conditions and contribute to an increased synucleinopathy risk (Mazzulli et al., 2011; Ulusoy & Di Monte, 2013). The gene discussed is SNCA; the disease is synucleinopathy.