SNCA and synucleinopathy: The initial link between α‐synuclein and human synucleinopathies was provided by genetic studies showing a causal relationship between a missense mutation, alanine to threonine, at position 53 (A53T) of the α‐synuclein gene (SNCA), and the development of autosomal‐dominant parkinsonism (Polymeropoulos et al., 1997).