In this study, we found that all three DVL family members were more abundantly localized in the nucleus of HCT-8/VCR cells compared to HCT-8 (Figure 7A and 7B), suggesting that the nuclear translocations of DVL1-3 were involved in MDR of CRC, and provided facilities for enhancing the nuclear complex formation of β-catenin/TCF. This evidence concerns the gene DVL1 and colorectal carcinoma.