Here, we found all three DVL family members (DVL1-3) were expressed at a higher level in vincristine-resistant CRC cells HCT-8/VCR compared to their parental cells HCT-8 (Figure 1A–1C), indicating that over-expression of DVL was involved in resistance of CRC to vincristine. This evidence concerns the gene DVL1 and colorectal carcinoma.