DVL1 and colorectal carcinoma: Data acquired showed that DVL1-3 was over-expressed in HCT-8/VCR cells compared with HCT-8, and HCT-8/VCR cells were more resistant to vincristine than HCT-8 cells (IC50 9.49 μM vs 1.23 μM) (Figure 1A–1C), suggesting that DVL was involved in CRC resistance to vincristine.