Given that DVL triggered the expression of P-gp, BCRP, MRP2, Survivin and Bcl-2 known as Wnt/β-catenin target genes via β-catenin, independently of the accumulation and nuclear translocation of β-catenin, we reasoned that DVL may function in transcription activity of β-catenin to trigger the Wnt/β-catenin target genes expression in CRC cells carrying APC mutant. This evidence concerns the gene APC and colorectal carcinoma.