Results based on the overexpression of miR-199a in low miR-199a-expressing NSCLC cells, and on inhibition with a specific HIF-1α inhibitor PX-478 suggest that miR-199a has an inhibitory effect on the hypoxia-induced proliferation of NSCLC cells, through negative regulation of HIF-1α and blocking of HIF-1α-mediated glycolysis [96]. Here, HIF1A is linked to non-small cell lung carcinoma.