In NSCLC tissues and cell lines, miR-497 targets different genes like vascular endothelial growth factor A (VEGF-A) [31], yes-associated protein 1 (YAP1) [32], cyclin E1 (CCNE1) [33], hepatoma-derived growth factor (HDGF) [34], and Bcl-2 [35]. This evidence concerns the gene HDGF and non-small cell lung carcinoma.