Unlocking the molecular interplay between these factors and their association with elevated bile acids (excessive DCA production) and cancer progression could shed light on the altered expression of key biochemical messengers, e.g. NF-kB and FXR (Figure 2), that when combined not only promote localised epithelium damage but also early stages of colorectal cancer [2]. The gene discussed is NR1H4; the disease is colorectal cancer.