Consistently, a significant increased tumor volume per nodule was observed in Oct3−/− in comparison to WT mice: on average, the majority of tumors of the Oct3−/− livers measured 1-5 mm in diameter, whereas the WT tumors, only showed diameters below 1 mm (p<0.0001) (Figure 2E). The gene discussed is SLC22A3; the disease is neoplasm.