As the Kaplan-Meier survival curve revealed, in total glioma patients (Figure 3Ap<0.001) and WHO II (Figure 3Bp=0.001), III (Figure 3Cp<0.001), patients with high HOXD4 expression have a significantly shorter OS than those with low HOXD4 expression. This evidence concerns the gene HOXD4 and central nervous system cancer.