CASP3 and gastrointestinal stromal tumor: To investigate whether TRAIL and FasL are implicated in reovirus-induced apoptosis, we evaluated caspase 3/7 activity and cell viability in GIST-T1 and GIST-IR cells after treatment with TRAIL alone, FasL alone, TRAIL in combination with reovirus, or FasL in combination with reovirus.