AR and prostate neoplasm: BPA binds to AR-T877A, displacing androgen hormone binding to its receptor in a non-competitive manner [14] and activates or potentiates the transcriptional activity of other functional AR mutated variants such as V715M, L701H and K580R (isolated from prostate tumor samples), and AR-T877S, AR-V715M and AR-H874Y (from human prostate carcinoma xenograft-derived 22Rv1 cells), whereas no effect was reported on wild-type AR [13].