AR and prostate adenocarcinoma: Accumulating evidence suggests that BPA affects prostate cells, thereby leading to proliferation of human prostatic adenocarcinoma LNCaP cells through activation of the endogenous androgen receptor (AR) mutant (AR-T877A) [13], and this has been suggested to favor transition of prostate tumors to castration-resistant prostate cancer (CRPC) with a unfavourable diagnosis and poor response to the current available therapies.