SHOC2 and colorectal carcinoma: To characterize the importance of the PKCα/δ phosphorylation of Sur8 in the FGF2-mediated cellular processes of CRC cells, we generated cell lines with wild type Sur8 (DLD-Sur8-WT) or phosphomimetic mutants (DLD-Sur8-T71E and DLD-Sur8-S297D) rescued in DLD-1 Sur8-KO cell lines (DLD-Sur8-KO).