To address the impact of the insertion on MCF2/DBL expression, we performed quantitative RT-PCR and detected a 28-fold increase in MCF2/DBL mRNA levels in the respective FH-hTERT-derived tumor, but not in primary FH-hTERT or in non-malignant regenerative FH-hTERT nodules in transplanted mouse livers (Figure 5C). The gene discussed is FH; the disease is neoplasm.