Several mutations in KCND3 were identified in dominantly inherited spinocerebellar ataxia (SCA) 19/22, early-onset of persistent lone atrial fibrillation, Brugada syndrome (BrS) and a case of sudden unexplained death [20, 22, 23, 31]. This evidence concerns the gene KCND3 and autosomal dominant cerebellar ataxia.