Figure 6G shows the statistically significant reverse correlations [Pearson correlation tests; r= −0.519, P<0.001 (NCI); r=-0.218, P=0.03 (Korean); r=-0.238, P<0.001 (Fudan)] between PRMT1 and CDKN1A. These results suggest that overexpressed PRMT1 in HCC can downregulate CDKN1A expression levels and subsequently may promote the proliferation and growth of cancer cells in response to various stimuli. This evidence concerns the gene CDKN1A and cancer.