PRDM9 and hepatocellular carcinoma: To elucidate whether these enzymes may be prognostic biomarkers in HCC, we examined the prognostic value of 20 histone methyltransferases and cancer outcomes using the gene expression data from the NCI patient cohort and selected PRMT1, which was most strongly associated with HCC patient overall survival (Supplementary Table 2 and Supplementary Figure 1).