DUSP1 is activated by phosphorylation on two Serine residues, Ser359 and Ser364 by ERK1/2 in human embryonic kidney (HEK) 293 cells; on the other hand, DUSP1 inactivates ERK1/2 by dephosphorylation in human bladder cancer HT1197 cells [23–25]. This evidence concerns the gene DUSP1 and urinary bladder cancer.