F4/80 protein expression, macrophage density, Ly6c density, Ly6c mRNA, Ly6c expression, apoptosis density, caspase 3 protein expression, ANP, TNF-α, IL-6, collagen 1, collagen 3, mRNA expression, collagen density, CD31 staining, and CD31 mRNA expression (Figure 8E-8S) were decreased in the SPK1−/− MI group and suppressed by atorvastatin treatment in the WT MI group. This evidence concerns the gene SPHK1 and myocardial infarction.