SPHK1 and infarction: AKT2 phosphorylation, NBA1, SPK1, SPK1 phosphorylation, F4/80 protein expression, F4/80 density, and hypertrophy marker ANP mRNA expression in the infarction area were promoted at day 7 after MI without treatment and diminished by atorvastatin treatment (Figure 7A-7G).