MMP2 and neoplasm: Celecoxib treatment also decreased the expression levels of Wnt pathway components and target genes, such as β-catenin, p-GSK-3β, MMP-2, Survivin, AXIN2, CYCLIN-D1 and C-MYC, and the CSC marker SOX-2 in the xenograft tumor tissues (Figure 6D and 6E).