Next, we assessed the susceptibility of melanoma cells grown in culture under hypoxic conditions to various targeted therapeutic agents, including PLX-4720 (B-Raf inhibitor), DAPT (Notch inhibitor), Genistein (protein-tyrosine kinase inhibitor), Ly294002 (PI3-Kinase inhibitor), MG-132 (Proteasome inhibitor), Rapamycin (mTOR inhibitors), SB2012190 (MAP kinase inhibitor), and U0126 (MEK inhibitor). This evidence concerns the gene BRAF and melanoma.