TP53 and neoplasm: While inducing the conditional deletion of Ino80 in adult mice had no effect on spontaneous tumor incidence, inducing Ino80 haploinsufficiency in a p53−/− background impacted cancer development by shifting the tumor type from lymphoma to sarcoma, which was suggested to be due to increased genomic instability and consequent defects in DNA repair and gene transcription involved in tumorigenesis [17].