Knocking down Ino80 using siRNA (Figure 4C) decreased the track length of ongoing forks in both HT29 (Figure 4D and 4E) and SW480 (Figure 4G and 4H) cells, indicating that as in HeLa and PC cells, INO80 plays a role in normal replication fork progression in colon cancer cells. The gene discussed is INO80; the disease is malignant colon neoplasm.