INO80 and small intestine neoplasm: However, we unexpectedly found that the average number of adenomatous polyps in the small intestines of the Ino80+/−Apcmin/+ mice was approximately 50% lower than the number in the Ino80+/+Apcmin/+ mice (Figure 1A and 1B), indicating that haploinsufficiency in Ino80 inhibited the development of small intestinal tumors.