BUB1B and neoplasm: Interestingly, there were significantly fewer tumors in the small intestines of BubR1+/−Apcmin/+ than were observed in Apcmin/+ mice, and there was a higher rate of apoptosis in the intestinal tumors of BubR1+/−Apcmin/+ mice, indicating that excessive aneuploidy promoted cell death and inhibited tumor growth [37].