Alternative splicing of genes has also been shown to be associated with SF3B1 mutations in breast cancer, such as TMEM14C, RPL31, CRNDE, DYNLL1, MZB1, ICA1, RPL24, MTERFD3, OBSL1, ABCC5, UQCC, GUSBP11, ANKHD1, ADAM12, F8, and GAS8 [11, 12]. The gene discussed is ICA1; the disease is breast cancer.