We found that SOCS3 knockdown in H460 cells with higher level of SOCS3, significantly promoted cell proliferation (Figure 3A, Supplementary Figure 2), anchorage-independent growth (3 fold; Figure 3B), cell migration and invasion (Figure 3C), and tumor growth in vivo (Figure 3D), suggesting a tumor-suppressive role of SOCS3 in NSCLC cells. This evidence concerns the gene SOCS3 and neoplasm.