MYC and neoplasm: In cancer, much focus has been placed on the role of GSK-3β in tumor progression and modulation of oncogenes (beta-catenin, cyclin D1, and c-MYC), cell cycle regulators (e.g., p27Kip1), and mediators of epithelial-mesenchymal transition (e.g., snail) by GSK-3β have been described (Figure 1A) [11–15].