PTEN and neoplasm: There were three pairs of genes that were mutated in a mutually exclusive pattern in tumor samples (n = 412): BRAF and NRAS mutations (Bonferroni adjusted p-value < 0.05), BRAF and NF1 mutations (Bonferroni adjusted p-value < 0.05), and NRAS and PTEN mutations (Bonferroni adjusted p-value < 0.05) (Table 2).